Alexis obtained his BSc (1994) and PhD (2000) in Chemistry at Universidad de Santiago de Chile (USACH) under the supervision of Dr. Eduardo Lissi exploring first in his bachelor thesis the physical chemistry of surfaces and organized systems and, later, for his PhD the protein oxidation mechanisms by free radicals and reactive oxygen species.
In 2001, Alexis joined Scaiano’s group as a postdoctoral fellow from Fundación Andes (Chile) and University of Ottawa. During his postdoc he was involved on the study of supramolecular sunscreens and the development of new strategies for evaluating antioxidant capacity using nitroxide prefluorescent probes. By the end of 2003, he returned to Chile as an Assistant Professor at the Faculty of Chemistry and Biology USACH. Only four years later of his return, he was promoted to Associate Professor and later in 2009 Alexis was awarded as a Distinguished Young Researcher by the university. Alexis has continued collaborating with our group and has frequently visited us as Visiting Research. He has also been Visiting Professor at Universidad Nacional de Santiago del Estero (Argentina) and CSIC-Madrid (Spain).
Alexis’ research has involved the study of oxidative damage induced by free radicals and reactive oxygen species, as well as the development of new tools and strategies to pinpoint the free radical processes affecting complex biological system. These strategies include the study of free radical processes and mechanisms involved in amino acid and protein oxidation by spontaneous weak level chemiluminescence, and the use of nitroxide pre-fluorescent probes to monitor free radical formation in constrained systems such as zeolites, polymer films, and proteins. Recently, the use of these probes was extended to evaluate polyphenolic antioxidants in hydrogen and/or electron transfer-based reactions towards nitroxides, both in homogeneous and in microheterogeneous systems [J Phys Chem A. 116,199-206 (2012)]. These methodologies have allowed a better understanding on antioxidant and free radical oxidation mechanisms in complex systems in concomitance with the use of time resolve techniques to monitor transient and free radical formation photoinduced by laser excitation of molecular probes and their reactions with proteins, amino acids, nitroxide, and phenolic antioxidants.
Alexis Aspée Lamas